TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/inNQc6x9Jy8
This Week in Pediatric Oncology #102 - November 10, 2022
Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined again by Dr. Douglas Hawkins - who is the current Chair of the Children’s Oncology Group (COG). They discuss in depth the findings of a presented published paper regarding the inequities of childhood cancer outcomes based on external socioeconomic factors such as neighborhood and household poverty.
To read the full paper, visit https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7936051&blobtype=pdf

TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ
Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors. 
 
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TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/rFd4Fwa_XVg
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids’ Cancer’s patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.
 
You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111
 
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q
In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments.
You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco
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TWiPO #89: Spotlight on Immunotherapy for Pediatrics - Natural Killer T-Cells with Dr. Andras Heczey

WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=nJZYz1XrsyY
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Andras Heczey from Texas Children's Hospital/Baylor College of Medicine. Listen in as they discuss Dr. Heczey's expertise & research in utilizing Natural Killer (NK) T-cells for pediatric immunotherapy treatment and the process of doing so.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #86: Oncolytic Virotherapy in Pediatric Brain Tumors with Dr. Gregory Friedman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/OSftR6JhEtY
As Brain Tumor Awareness Month draws to a close, we bring you a new TWIPO episode on the subject. Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Gregory Friedman from the University of Alabama in Birmingham to discuss his recently published paper “Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.” Listen in as Dr. Friedman discusses the findings of this phase 1 clinical trial and the progress of oncolytic virotherapy in pediatric brain tumors.
You can access the abstract to Dr. Friedman's paper here: https://pubmed.ncbi.nlm.nih.gov/33838625/
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TWiPO #83 - Dr. Christopher Dandoy on transplant-associated thrombotic microangiopathy (TA-TMA)

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/io13HbVwtbI
Hosts Tim Cripe and Brenda Weigel welcome Dr. Chris Dandoy, from Cincinnati Children's Hospital, and parent advocate, Sarah Moore, to discuss the current research on TA-TMA and the implications for children undergoing stem cell transplant (SCT) for pediatric cancers, notably tandem SCTs for high-risk neuroblastoma.
 
Dr. Dandoy is Assistant Professor of Clinical Pediatrics in Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children’s Hospital Medical Center and this episode discussion focused on four recently published papers by Dr. Dandoy describing effects, incidence, risk factors, screening, and treatment of this serious complication of transplants. Sarah Moore also shared her perspective as a mother to a child who recently underwent tandem SCT for high-risk neuroblastoma, and has been active in parent forums discussing the incidence and implications of TA-TMA and sharing evidence-based information.
 
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
 
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TWIPO #66 - Interview with Dr. Rani George

Host Dr. Ryan Roberts, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Rani George to discuss her experience with studying neuroblastoma and how she got involved in the field of oncology. George discusses her thoughts on what is needed to progress pediatric cancer research - including relapse biopsies, understanding the biology, and, of course, funding. As Dr. Roberts says, what we need is, "...more time, more patience, and more funding."  Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPo #59 ~ Interview with Dr. Sajid Qureshi

Host Dr. Timothy Cripe and co-Host Nilay Shah interview Dr. Sajid Qureshi, a professor of Pediatric Oncology at the Tata Memorial Center, Mumbai, India. Dr. Qureshi is an Executive Committee Member of the International Society of Pediatric Surgical Oncology (IPSO). In this episode Dr. Qureshi provides a fascinating, first-hand glimpse into the successes and challenges of delivering quality care to larger, as well as remote, pediatric cancer populations. The episode concludes with Dr. Qureshi's thoughts on how international research collaboration could provide access to relapsed children worldwide.

TWiPO #58 ~ Interview with Dr. Damon Reed

TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development.