This Week in Pediatric Oncology

TWiPO #3 ~ Vincristine Pharmacogenetics, Irinotecan/Temozolomide for Relapsed Neuroblastoma

April
25, 2011
In this third episode, host Tim Cripe, MD, PhD,
asks his co-hosts to discuss two recent papers that provide new information
about genetic predisposition to increased toxicity to vincristine in some
children, and the results of a phase II study using a combination therapy
(irinotecan and temozolomide) in relapsed or refractory neuroblastoma.
1:24 Maureen
O'Brien, MD discusses "Increased risk of vincristine neurotoxicity
associated with low CYP3A5 expression genotype in children with acute
lymphoblastic leukemia" in Pediatr Blood Cancer. 2011 Mar;56(3):361-7.
doi: 10.1002/pbc.22845. Epub 2010 Nov 11.http://www.ncbi.nlm.nih.gov/pubmed/21225912
22:10 Lars
Wagner, MD discusses "Phase II study of irinotecan and temozolomide in
children with relapsed or refractory neuroblastoma: a Children's Oncology Group
study" from J Clin Oncol. 2011 Jan 10;29(2):208-13. Epub 2010 Nov
29. http://www.ncbi.nlm.nih.gov/pubmed/21115869

TWiPO #2 ~ Interview with Greg Reaman

April
13, 2011
In this second episode of TWiPO, host Dr. Tim
Cripe interviews Dr. Gregory Reaman about his career in pediatric oncology,
leadership of the COG, challenges, and expectations for the future.

TWiPO #1 ~ Epidemiology of Childhood Cancer

April
11, 2011
Solving Kids' Cancer is sponsoring a free
podcast series for researchers, clinicians, advocates, and others focusing on
pediatric cancer research, hosted by physician-scientist Dr. Timothy Cripe and colleagues at Cincinnati Children's.
Podcasts will be published 2 to 4 times per month with discussions on new
publications, clinical trials, interviews with thought leaders, and more.
This
first episode is a discussion among the pediatric oncologists about the
recently published paper in Journal of Clinical Oncology "Outcomes for
Children and Adolescents With Cancer: Challenges for the Twenty-First
Century" (J Clin Oncol 28:2625-2634)