This Week in Pediatric Oncology

The Pandemic’s Impact on the Pediatric Cancer Research Landscape

• How is the pandemic changing current cancer care services?
• What is the current state of open clinical trials and how will new, near-term trials be affected?
• What is the impact on emerging new therapies and translational research?
• Are there any silver linings to all of this for childhood cancer research?

These answers and more are discussed in this special episode for cancer families where leaders from COG, the NCI and the pharmaceutical industry lead a community discussion about the pandemic's impact on all aspects of pediatric cancer research including clinical trials and standard cancer care services, followed by Q&A with questions from families and attendees.

 

We are joined by:
- Peter Adamson, MD – former Chair, Children's Oncology Group (COG) and current Global Head, Oncology Development & Pediatric Innovation, Sanofi

- Mark Kieran, MD, PhD – Pediatric Clinical Trial Lead, Bristol Myers Squibb

- Jeffery J. Auletta, MD - Director of the Blood and Marrow Transplant (BMT) Program and the Host Defense and Immunocompromised Infectious Diseases Program at Nationwide Children's Hospital.

- Carol Thiele, Ph.D, Deputy Chief, National Cancer Institute (NCI) Pediatric Oncology Branch

- Prof. Pamela Kearns President, European Society of Pediatric Oncology (SIOPE), Director of Cancer Research UK Clinical Trials Unit

Moderated by: Timothy P. Cripe, MD, PhD – Chief of Hematology and Oncology at Nationwide Children’s Hospital

Hosted by: Solving Kids' Cancer US & UK, and Max Cure Foundation

Latest COVID-19 Insights from Doctors + Stories from the Frontline to inform Childhood Cancer Families & the General Community

Experts from the medical community will update us on our progress to-date and what to expect in the coming weeks and months. Also, parents from a New York family both diagnosed with COVID-19 will share their family’s current story/experience and important insights from the frontline.

Please join this timely webinar to hear expert opinions, real-life descriptions, ask questions, and share information on:

• Progress on containing and treating the virus
• Could viruses like COVID-19 be the new normal?
• Medical services to pediatric cancer patients – how much of a delay right now?
• Clinical research trials for cancer and other diseases on hold – impact to getting new treatments developed
• Sharing a personal story: Real life with COVID-19 from a family’s perspective in New York

Q&A to follow

Guest Speakers:
• Timothy P. Cripe, MD, PhD, Chief of Hematology and Oncology, Nationwide Children’s Hospital
• Jeffery J. Auletta, MD, Director of the Blood and Marrow Transplant (BMT) Program and Host Defense and Immunocompromised Infectious Diseases – Nationwide Children’s Hospital
• New York couple diagnosed with COVID-19 at home with their family

Discussion on Impact of COVID-19 in the Pediatric Cancer Community

As our world faces the Novel Coronavirus pandemic, it’s vital that we address key topics important to children & families in the Pediatric Cancer Community

Please listen to this informative webinar to hear from experts, ask questions, and share information on:
- An overview of COVID-19 pandemic: Fact versus fiction
- COVID-19: What are the risks to immunocompromised patients?
- Impact of COVID-19 on care and clinical research

Expert Discussion Leaders:
Timothy P. Cripe, MD, PhD – Chief of Hematology and Oncology at Nationwide Children’s Hospital

Jeffery J. Auletta, MD - Director of the Blood and Marrow Transplant (BMT) Program and the Host Defense and Immunocompromised Infectious Diseases Program at Nationwide Children's Hospital.

 

This audio was taken from a webinar, to watch the full video with resources click here: https://vimeo.com/400382067

TWiPO #76 - Rebecca Johnson & Becca Jacobsen discuss Adolescent/Young adult psycho-social support programs

Guest host Dr. Ryan Roberts welcomes Rebecca Johnson and Becca Jacobsen to a conversation about the benefits and contributions of AYA (Adolescent/Young Adult) psycho-social support programs which serve the needs and challenges within this demographic of cancer patients and survivors.

TWiPO #75 - Interview with Dr. Robert Wechsler-Reya

Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with co-host - Dr. Nilay Shah, are joined by Dr. Robert Wechsler-Reya from Sanford Burnham Prebys in San Diego, CA. They discuss Dr. Wechsler-Reya's work including the process, benefits, and limitations of tumor models in mice, as well as research behind the humanized mouse model. They also discuss immune evasion - how one tumor type can grow in the presence of an immune system, while another one cannot. Listen in to learn more.

Please send questions and comments to TWiPO@solvingkidscancer.org.

TWiPO #74 - Interview with Abby Rosenberg

TWIPO Host Tim Cripe, alongside co-hosts Ryan Roberts and Lisa Humphrey, engage in an insightful conversation with guest Abby Rosenberg, Director, Palliative Care and Resilience Research at Seattle Children's Research Institute.

Rosenberg, with Seattle Children’s colleague, Yi-Frazier, developed a promising systematic intervention program called PRISM (Promoting Resilience in Stress Management) for teens and young adults to better equip them with skills to manage their stress after a cancer diagnosis. PRISM has undergone pilot/feasibility studies and has received NIH funding for further study. Listen in to learn more.

Please send questions and comments to TWiPO@solvingkidscancer.org.

 

TWiPO #73 - Dr. Peter Adamson comes back to talk about progress, the drug shortage, families’ impact, and so much more

Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with his co-hosts - Dr. Ryan Roberts, Dr. Nilay Shah, Dr. Keri Streby, and Dr. Mark Ranalli, interview Dr. Peter Adamson from Children's Hospital of Philadelphia. Dr. Adamson was previously interviewed back in 2011, in Podcast #9, and they discuss the progress that has been made since then. Dr. Adamson goes on to talk about private-public partnerships, families' impact on the field, the drug shortage problem, and much more. Tune in to this podcast to learn more about all of these interesting topics.

TWiPO #72 - Dr. Eugene Hwang discusses his work with immunotherapy and pseudo-progression

Hosts, Dr. Timothy Cripe, Dr. Keri Steby, Dr. Ryan Roberts, and Dr. Jonathan Finlay from Nationwide Children's Hospital are joined by Dr. Eugene Hwang, who is a pediatric hematologist-oncologist at the Children's National Medical Center in Washington D.C. Dr. Hwang discusses his work with immunotherapy and pseudo-progression, as well as explains the basics of a solid tumor clinical trial he created in conjunction with Dr. Catherine Bollard. Listen in to learn more.

TWiPO #71 - Interview with Nancy Goodman, Founder and Executive Director of Kids v. Cancer

Host, Dr. Timothy Cripe, from Nationwide Children's Hospital in Columbus, Ohio had the honor of interviewing Nancy Goodman, Founder and Executive Director of Kids v. Cancer in Washington DC.

TWiPO #70 - Dr. Joshua Rubin talks about his research done on gender differences to cancer

Dr. Joshua Rubin, from Washington University, discusses his research done of gender differences to cancer that go beyond hormonal differences

TWiPO #69 - Dr. Peter Shields talks about the effects of e-cigarettes

Dr. Shields discusses his research on cigarettes and the effects of e-cigarettes among its users, the youth, and the economy.

TWiPO #68 - Dr. Dean Lee discusses his experience with T-cell CARs

Host Dr. Timothy Cripe and Dr. Nilay Shah, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Dean Lee to discuss their experience with T-cell CARs (Chimeric Antigen Receptors).

TWiPO #67 - Interview with Dr. Mitchell Cairo

Hosts Dr. Nilay Shah, Dr. Ryan Roberts, and Dr. Keri Streby from Nationwide Children’s Hospital in Columbus, Ohio, sit down with Dr. Mitchell Cairo to discuss his experiences within the pediatric cancer research sector.

TWIPO #66 - Interview with Dr. Rani George

Host Dr. Ryan Roberts, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Rani George to discuss her experience with studying neuroblastoma and how she got involved in the field of oncology. George discusses her thoughts on what is needed to progress pediatric cancer research - including relapse biopsies, understanding the biology, and, of course, funding. As Dr. Roberts says, what we need is, "...more time, more patience, and more funding."  Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #65 - Interview with Dr. Brenda Weigel

In this podcast, co-Hosts Dr. Robyn Dennis and Dr. Ryan Roberts had the honor of interviewing Dr. Brenda Weigel, Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota. Dr. Weigel discusses her “serendipitous” background story of how she became involved in childhood oncology, as well as talks about the challenges the field faces with managing new cancer therapies. But, despite the challenges, she is hopeful that we are moving away from chemotherapy treatments into an era of cancer therapies that “hopefully, has the potential to cure the cancers and improve the quality of life”. 

TWiPO #64 - Interview with Dr. Lars Wagner

It’s an exciting time to be part of the childhood cancer research community, and this interview was focused on career advice for those interested in childhood oncology and research. The availability of genomic profiling of tumors, targeted agents and the development of new immunotherapies are increasing the opportunities available to patients today. This lively discussion addresses the importance of preclinical data, predictive biomarker studies and the measurement of responses, with specific references to Dr. Wagner’s experience with studying irinotecan.   Dr. Wagner also answered questions about radiomics and how this imaging trend can provide more insights for enhanced radiology reporting.

Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #63 - Dr. Javier Blanco discusses chemotherapy late effects and cardio-toxicity

Co-Hosts Dr. Timothy Cripe and Dr. Randal Olshefski (Nationwide Children's Hospital), interview Dr. Javier Blanco, Associate Professor at the Department of Pharmaceutical Sciences at SUNY Buffalo, about the late effects of chemotherapy.  In this podcast, the participants discuss the role that chemotherapy, such as doxorubicin and other anthracycline drugs, often play in increasing cardio-toxicity.

TWiPO #62 - Interview with Dr. Uri Tabori

TWiPO hosts and cohosts interview Dr. Uri Tabori about the challenges that are unique to pediatric brain tumors, and how preventative treatment and early diagnosis can be largely beneficial.  

TWIPO #61 - Interview with Dr. Matthew Breen

TWIPO hosts and cohosts interview Dr. Matthew Breen, NC State Veterinary Medicine, to explore the question "Can dogs teach us new tricks when it comes to cancer treatment?"

TWIPO #60 - Interview with Dr. Josua Mendell

TWIPO hosts and cohosts interview Dr. Joshua Mendell, UT Southwestern Medical Center, who shares his knowledge with regard to the relationship between innate RNA biology and how it influences human disease.