This Week in Pediatric Oncology

This Week in Pediatric Oncology header image 1

TWiPO #53 ~ Interview with Linda McAllister-Lucas

April 13th, 2016

On today's podcast TWiPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-hosts, Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Robyn Dennis (Nationwide Children’s Hospital) Interview Dr. Linda McAllister-Lucas (Chief of Service, Hematology/Oncology of Children's Hospital of Pittsburgh, Associate Professor of Pediatrics, University of Pittsburgh School of Medicine. In their discussion Dr. McAllister-Lucas talks about her research on MALT1 Lymphoma and how this research could advance the field of oncology 

00:0000:00

TWIPO #52 ~ Interview with Dr. James Geller

December 9th, 2015

On this TWiPO episode hosts, Dr. Timothy Cripe and Dr. Nilay Shah (Nationwide Children’s Hospital) interview Dr. James Geller (Medical Director at Kidney and Liver Tumors Program, Co-Medical Director at Retinoblastoma Program, Associate Director at Global Cancer Programs, Associate Professor at UC Department of Pediatrics.) Dr. James Geller was one of the original TWiPO members back in 2010. Today Dr. Geller talks about the battle to get access to potential drugs (Ex. Lorvotuzumab [IMGN901]) that can be beneficial to treating pediatric cancers.

00:0000:00

TWIPO #51 ~ Interview with Dr. Gregory Armstrong

November 2nd, 2015

This week in pediatric oncology TWiPO hosts Dr. Timothy Cripe, Robyn Dennis, MD, Dr. Nilay Shah interview Dr. Gregory Armstrong (Associate Professor in  the Department of pediatrics at the University of Tennessee health science center, Associate member of in the department of epidemiology in cancer control in Saint Jude's Children's Research Hospital, Director of CNS tumor after completion of therapy clinic at Saint Jude). Dr. Armstrong and hosts discuss the Childhood Cancer Survival Study (CCSS) and the advancements we have made in the field of oncology. Along with problems that they are working to solve.

00:0000:00

TWIPO #50 ~ Interview With Dr. Jonathan Finlay

May 8th, 2015

In this most recent TWiPO podcast hosted by Dr. Timothy Cripe (Nationwide Children’s Hospital), he interviews Dr. Jonathan Finlay (Program Director of Neuro-Oncology at Nationwide Children’s Hospital) about sparked in research interest in brain tumors. One of Dr. Finlay’s mentors, helped launch a new treatment, which was able to rescue a proportion of newly diagnosed children who failed conventional chemotherapy, radiation, and surgery. That novel treatment is now a growing method of treating medulloblastoma.

00:0000:00

TWIPO #49 ~ Interview With Dr. Robin Norris

April 20th, 2015

TWiPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and TWiPO co-host Dr. Nilay Shah (Nationwide Children’s Hospital) interview Robin Norris, MD, who is a pediatric oncologist and the Director of the Pediatric Developmental Therapeutics Program, Division of Pediatric Hematology and Oncology, at University Hospitals Rainbow Babies & Children's Hospital. Dr. Norris discusses the struggles that adolescents and young adult with cancer face and discusses her involvement in creating an antibody against TEM-1 in order to stop the metastasis of tumors.

00:0000:00

TWIPO #48 ~ Interview With Dr. Michael D. Hogarty

April 20th, 2015

TWiPO host Dr. Nilay Shah (Nationwide Children’s Hospital) interviews Dr. Michael D. Hogarty, MD, an attending physician in the Division of Oncology at The Children's Hospital of Philadelphia. Dr. Hogarty recalls his efforts in finding a new way of tackling neuroblastoma by sending 17,000 tumor samples around the world. In this short interview, he discusses his current work in the lab, which involves testing the MYC gene found in children with high-risk neuroblastoma.

00:0000:00

TWIPO #47 ~ Interview With Dr. Hiro Shimada

March 30th, 2015

TWiPo co-hosts Dr. Keri Stretby (Nationwide Children’s Hospital) and Dr. Nilay Shah (Nationwide Children’s Hospital) interview Hiroyuki Shimada, MD, PhD, Professor of Clinical Pathology at the Children’s Hospital of Lost Angeles. Dr. Shimada developed the Shimada neuroblastoma classification system for neuroblastoma, which was the basis of The International Neuroblastoma Pathology Classification and now The International Neuroblastoma Risk Group classification system.

00:0000:00

TWIPO #46 ~ ANR Recap: Interview With Dr. Sue Cohn

March 30th, 2015

TWiPO host Dr. Nilay Shah (Nationwide Children’s Hospital) interviewed Susan L. Cohn, MD, a Professor of Pediatrics, Dean of Clinical Research at the University of Chicago at the ANR meeting in Cologne, Germany last year for this episode of This Week in Pediatric Oncology. Dr. Cohn is a highly respected expert in pediatric cancers and blood diseases. She is a leading authority on neuroblastoma and actively researching several aspects of neuroblastoma. Her research has received generous support from the National Institutes of Health/National Cancer Institute and the National Institute of Neurological Disorders and Stroke. Dr. Shaw and Dr. Cohn discuss the future of neuroblastoma research and clinical trial design to create more effective treatment options for children with high-risk disease.

00:0000:00

TWIPO #45 ~ Immunotherapy Vaccine for Immunotherapy Vaccine for High-Grade Gliomas

November 18th, 2014

In the most recent episode of This Week in Pediatric Oncology, co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital), Dr. Timothy Cripe (Nationwide Children’s Hospital), and Dr. Lionel Chow (Cincinnati Children’s) discuss the promising results of a study published in the July issue of Journal of Clinical Oncology among children with an aggressive brain tumor after receiving immunotherapy. To see a summary of the study, click here

00:0000:00

TWIPO #44 ~ ANR Recap: Interview With Professor Michelle Haber and Professor Andrew Pearson

November 10th, 2014

In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Keri Stretby (Nationwide Children’s Hospital) and Dr. Nilay Shah (Nationwide Children’s Hospital), caught up with Professor Michelle Haber (Executive Director at Children’s Cancer Institute in Australia and Professor Andrew Pearson of the Cancer Research UK. In this 26-minute podcast, both researchers discuss the future of neuroblastoma, specifically looking at precision medicine, the role of gene sequencing and the role of international collaboration to bring new therapies into the clinic.

00:0000:00

TWIPO #43 ~ Langerhans cell histiocytosis : Interview With Carl E. Allen

October 1st, 2014

New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Edwin Horwitz (Nationwide Children’s Hospital), Dr. Nilay Shah (Nationwide Children’s Hospital),  Dr. Robyn Dennis (Nationwide Children's Hospital), interview Dr.  Carl E. Allen, (Texas Children’s Cancer and Hematology Centers) about his research in a rare pediatric blood disorder known as Langerhans cell histiocytosis (LCH).

Dr. Allen is Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology - Baylor College of Medicine, and the Co-Director of the Histiocytosis and Lymphoma Programs at Texas Children's Cancer and Hematology Centers.  His primary research is focused on the clinical and biologic aspects of LCH.  Along with Dr. Kenneth McClain, Dr. Carl Allen has developed the largest Histiocytosis Center in the world.  Dr. Allen has developed gene expression and proteomic strategies to analyze the identity and function of the cells that cause LCH.  The ultimate goal of these experiments is to identify genes, proteins, and pathways that may be used to diagnose and cure patients with LCH.  These experiments may also provide insight into dendritic cell biology and tumor immunology.

In this 20-minute episode, Dr. Allen gives an overview of LCH, as well as treatment and the future of LCH research.


 

00:0000:00

TWIPO #42 ~ Advances in Neuroblastoma Research Meeting Recap: Interview With Frank Berthold

July 23rd, 2014

New York – This Week in Pediatric Oncology presents the third and final interview from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) talk with Frank Berthold, ANR2014 Local Chairman, to discuss meeting highlights in the short, 18-minute interview.  

00:0000:00

TWIPO #41 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MIBG Therapy

July 15th, 2014

New York – This Week in Pediatric Oncology presents the second in a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) discuss MIBG therapy in treating children with high-risk neuroblastoma with Dr. Kate Matthay (UCSF Benioff Children's Hospital) and Dr. Gregory Yanik (C.S. Mott Children’s Hospital at the University of Michigan). In this 45-minute interview, both Drs. Matthay and Yanik, who have conducted extensive research in MIBG throughout their long careers, share their perspectives on what’s going on in the field now and opportunities to improve the therapy in the future.

00:0000:00

TWIPO #40 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MYCN

July 10th, 2014

New York – This Week in Pediatric Oncology presents the first of a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) caught up with two pediatric oncologists who’ve made significant advances in neuroblastoma research. In this 25-minute interview, Dr. Robert Seeger (Children's Hospital of Los Angeles) and Dr. Garrett Brodeur (Children’s Hospital of Philadelphia) discuss how the discovery of the MYCN gene 30 years ago has helped scientists better understand neuroblastoma and impacted treatment options.

00:0000:00

TWIPO #39 ~ Declining Childhood Cancer Mortality & CAR123 T-cells

July 10th, 2014

New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Timothy Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), Dr. Andy Kolb (A.I. Dupont) and Dr. Lionel Chow (Cincinatti Children's) discuss two recent papers on the declining mortality rate in childhood and adolescent cancers and a pre-clinical study using CAR123 T-cells.


Saar Gill, Sarah K. Tasian, Marco Ruella, Olga Shestova, Yong Li, David L. Porter, Martin Carroll, Gwenn Danet-Desnoyers, John Scholler, Stephan A. Grupp, Carl H. June, and Michael Kalos. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells. Blood. 2014, 10, April. http://www.ncbi.nlm.nih.gov/pubmed/24596416

00:0000:00

TWIPO #38 ~ Interview with John Goldberg, MD, on Phase I Clinical Trials

March 11th, 2014

March 11, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that John Goldberg, MD, from The Sylvester Comprehensive Cancer Center at the University of Miami, is a featured guest on its most recent episode. In this episode, Dr. Golberg talks about the challenges of phase I pediatric cancer clinical trials with hosts Dr. Tim Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), and Mark Ranalli, MD (Nationwide Children's Hospital).

Dr. Goldberg is an Assistant Professor of Pediatrics and the Director of the Pediatric Oncology Early Phase Clinical Trials Program at The Sylvester Comprehensive Cancer Center, the University of Miami.

00:0000:00

TWIPO #37 ~ Interview with Patrick Brown, MD, on Infant Leukemia

February 26th, 2014

February 26, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Patrick Brown, MD, from The Sidney Kimmel Comprehensive Cancer Center, is a featured guest on its most recent episode. In this episode, Dr. Brown  talks about treating infant leukemia and the challenges of doing clinical trials in this patient population with hosts Dr. Tim Cripe (Nationwide Children's Hospital) and Dr. Robyn Dennis (Nationwide Children's Hospital).

Dr. Brown is the Director, Pediatric Leukemia and Lymphoma Program and Associate Professor of Oncology and Assistant Professor of Pediatrics at The Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins School of Medicine. 

00:0000:00

TWIPO #36 ~ Interview With Kathleen Neville, MD, on Pediatric Drug Development

February 10th, 2014

January 27, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Kathleen Neville,MD, from Children's Mercy Hospital in Kansas City, is a featured guest on its most recent episode. In this episode, Dr. Kathleen Neville talks about the challenges of drug development in pediatric cancer with with host Dr. Tim Cripe (Nationwide Children's Hospital).

Kathleen Neville is the Director of Experimental Therapeutics in the pediatric cancer program at Children's Mercy Hospital in Kansas City. She is an Associate Professor of Pediatrics in the division of pediatric clinical pharmacology, medical toxicology and hematology-oncology at the University of Missouri-Kansas City School of Medicine. She is also the chair of the education committee of the American Society for Clinical Pharmacology and Therapeutics, and a consultant on FDA pediatric advisory committee, and serves on the FDA Pediatric Oncology Subcommittee of the Oncologic Drugs Advisory Committee.

00:0000:00

TWIPO #35 ~ Interview With Robert Johnson, PhD

February 10th, 2014

December 02, 2013

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Robert Johnson, PhD, is a featured guest on its most recent episode, In this episode, Dr. Johnson speaks with host Dr. Tim Cripe (Nationwide Children's Hospital) and co-hosts Dr. Robyn Dennis (Nationwide Children's Hospital and Dr. Lionel Chow (Cincinatti Children's) about the third most common type of brain tumor in children, ependymomas.

Robert A. Johnson, PhD, is a principal investigator at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of the Johnson laboratory is the development of novel therapies for the treatment of ependymoma, the third most common pediatric brain tumor, by identifying and targeting the genetic changes responsible for the formation of the disease.

00:0000:00

TWIPO #34 ~Interview With Dr. Nancy Ratner

February 10th, 2014

November 14, 2013

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Nancy Ratner, PhD, is a featured guest on its most recent episode, In this episode, Dr. Ratner speaks with host Dr. Tim Cripe (Nationwide Children's Hospital) and co-host Dr. Robyn Dennis (Nationwide Children's Hospital).

Dr. Ratner is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST.

Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders Institute where she holds the Beatrice C. Lampkin Endowed Chair in Cancer Biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research.”

00:0000:00