This Week in Pediatric Oncology

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TWIPO #44 ~ ANR Recap: Interview With Professor Michelle Haber and Professor Andrew Pearson

November 10th, 2014

In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Keri Stretby (Nationwide Children’s Hospital) and Dr. Nilay Shah (Nationwide Children’s Hospital), caught up with Professor Michelle Haber (Executive Director at Children’s Cancer Institute in Australia and Professor Andrew Pearson of the Cancer Research UK. In this 26-minute podcast, both researchers discuss the future of neuroblastoma, specifically looking at precision medicine, the role of gene sequencing and the role of international collaboration to bring new therapies into the clinic.

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TWIPO #43 ~ Langerhans cell histiocytosis : Interview With Carl E. Allen

October 1st, 2014

New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Edwin Horwitz (Nationwide Children’s Hospital), Dr. Nilay Shah (Nationwide Children’s Hospital),  Dr. Robyn Dennis (Nationwide Children's Hospital), interview Dr.  Carl E. Allen, (Texas Children’s Cancer and Hematology Centers) about his research in a rare pediatric blood disorder known as Langerhans cell histiocytosis (LCH).

Dr. Allen is Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology - Baylor College of Medicine, and the Co-Director of the Histiocytosis and Lymphoma Programs at Texas Children's Cancer and Hematology Centers.  His primary research is focused on the clinical and biologic aspects of LCH.  Along with Dr. Kenneth McClain, Dr. Carl Allen has developed the largest Histiocytosis Center in the world.  Dr. Allen has developed gene expression and proteomic strategies to analyze the identity and function of the cells that cause LCH.  The ultimate goal of these experiments is to identify genes, proteins, and pathways that may be used to diagnose and cure patients with LCH.  These experiments may also provide insight into dendritic cell biology and tumor immunology.

In this 20-minute episode, Dr. Allen gives an overview of LCH, as well as treatment and the future of LCH research.


 

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TWIPO #42 ~ Advances in Neuroblastoma Research Meeting Recap: Interview With Frank Berthold

July 23rd, 2014

New York – This Week in Pediatric Oncology presents the third and final interview from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) talk with Frank Berthold, ANR2014 Local Chairman, to discuss meeting highlights in the short, 18-minute interview.  

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TWIPO #41 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MIBG Therapy

July 15th, 2014

New York – This Week in Pediatric Oncology presents the second in a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) discuss MIBG therapy in treating children with high-risk neuroblastoma with Dr. Kate Matthay (UCSF Benioff Children's Hospital) and Dr. Gregory Yanik (C.S. Mott Children’s Hospital at the University of Michigan). In this 45-minute interview, both Drs. Matthay and Yanik, who have conducted extensive research in MIBG throughout their long careers, share their perspectives on what’s going on in the field now and opportunities to improve the therapy in the future.

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TWIPO #40 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MYCN

July 10th, 2014

New York – This Week in Pediatric Oncology presents the first of a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) caught up with two pediatric oncologists who’ve made significant advances in neuroblastoma research. In this 25-minute interview, Dr. Robert Seeger (Children's Hospital of Los Angeles) and Dr. Garrett Brodeur (Children’s Hospital of Philadelphia) discuss how the discovery of the MYCN gene 30 years ago has helped scientists better understand neuroblastoma and impacted treatment options.

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TWIPO #39 ~ Declining Childhood Cancer Mortality & CAR123 T-cells

July 10th, 2014

New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Timothy Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), Dr. Andy Kolb (A.I. Dupont) and Dr. Lionel Chow (Cincinatti Children's) discuss two recent papers on the declining mortality rate in childhood and adolescent cancers and a pre-clinical study using CAR123 T-cells.


Saar Gill, Sarah K. Tasian, Marco Ruella, Olga Shestova, Yong Li, David L. Porter, Martin Carroll, Gwenn Danet-Desnoyers, John Scholler, Stephan A. Grupp, Carl H. June, and Michael Kalos. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells. Blood. 2014, 10, April. http://www.ncbi.nlm.nih.gov/pubmed/24596416

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TWIPO #38 ~ Interview with John Goldberg, MD, on Phase I Clinical Trials

March 11th, 2014

March 11, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that John Goldberg, MD, from The Sylvester Comprehensive Cancer Center at the University of Miami, is a featured guest on its most recent episode. In this episode, Dr. Golberg talks about the challenges of phase I pediatric cancer clinical trials with hosts Dr. Tim Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), and Mark Ranalli, MD (Nationwide Children's Hospital).

Dr. Goldberg is an Assistant Professor of Pediatrics and the Director of the Pediatric Oncology Early Phase Clinical Trials Program at The Sylvester Comprehensive Cancer Center, the University of Miami.

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TWIPO #37 ~ Interview with Patrick Brown, MD, on Infant Leukemia

February 26th, 2014

February 26, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Patrick Brown, MD, from The Sidney Kimmel Comprehensive Cancer Center, is a featured guest on its most recent episode. In this episode, Dr. Brown  talks about treating infant leukemia and the challenges of doing clinical trials in this patient population with hosts Dr. Tim Cripe (Nationwide Children's Hospital) and Dr. Robyn Dennis (Nationwide Children's Hospital).

Dr. Brown is the Director, Pediatric Leukemia and Lymphoma Program and Associate Professor of Oncology and Assistant Professor of Pediatrics at The Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins School of Medicine. 

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TWIPO #36 ~ Interview With Kathleen Neville, MD, on Pediatric Drug Development

February 10th, 2014

January 27, 2014

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Kathleen Neville,MD, from Children's Mercy Hospital in Kansas City, is a featured guest on its most recent episode. In this episode, Dr. Kathleen Neville talks about the challenges of drug development in pediatric cancer with with host Dr. Tim Cripe (Nationwide Children's Hospital).

Kathleen Neville is the Director of Experimental Therapeutics in the pediatric cancer program at Children's Mercy Hospital in Kansas City. She is an Associate Professor of Pediatrics in the division of pediatric clinical pharmacology, medical toxicology and hematology-oncology at the University of Missouri-Kansas City School of Medicine. She is also the chair of the education committee of the American Society for Clinical Pharmacology and Therapeutics, and a consultant on FDA pediatric advisory committee, and serves on the FDA Pediatric Oncology Subcommittee of the Oncologic Drugs Advisory Committee.

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TWIPO #35 ~ Interview With Robert Johnson, PhD

February 10th, 2014

December 02, 2013

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Robert Johnson, PhD, is a featured guest on its most recent episode, In this episode, Dr. Johnson speaks with host Dr. Tim Cripe (Nationwide Children's Hospital) and co-hosts Dr. Robyn Dennis (Nationwide Children's Hospital and Dr. Lionel Chow (Cincinatti Children's) about the third most common type of brain tumor in children, ependymomas.

Robert A. Johnson, PhD, is a principal investigator at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of the Johnson laboratory is the development of novel therapies for the treatment of ependymoma, the third most common pediatric brain tumor, by identifying and targeting the genetic changes responsible for the formation of the disease.

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TWIPO #34 ~Interview With Dr. Nancy Ratner

February 10th, 2014

November 14, 2013

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Nancy Ratner, PhD, is a featured guest on its most recent episode, In this episode, Dr. Ratner speaks with host Dr. Tim Cripe (Nationwide Children's Hospital) and co-host Dr. Robyn Dennis (Nationwide Children's Hospital).

Dr. Ratner is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST.

Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders Institute where she holds the Beatrice C. Lampkin Endowed Chair in Cancer Biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research.”

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TWIPO #33 ~Effective Advocacy

February 10th, 2014

October 31, 2013

New York, NY—This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Gavin Lindberg is a featured guest on its most recent episode, entitled Effective Advocacy. In this episode, Mr. Lindberg speaks with host Dr. Tim Cripe (Nationwide Children’s Hospital), and co-host Dr. Robyn Dennis (Nationwide Children’s Hospital), about his work to increase funding for childhood cancer research.

Mr. Lindberg is the President and Co-Founder of The Evan’s Victory Against Neuroblastoma (EVAN) Foundation, which was established in memory of his only child Evan Lindberg. Evan bravely battled neuroblastoma for four years before passing away at the age of 7 in 2010. The Foundation funds research aimed at fostering new therapies for children with neuroblastoma, and sponsors patient-wellness programs for childhood cancer patients enduring long and difficult stays in the hospital.

While his son was in treatment, Mr. Lindberg served as the founding president of the Band of Parents, an organization that raised over $1 million to develop a new humanized antibody for neuroblastoma currently used at Memorial Sloan-Kettering Cancer Center, in New York City. Mr. Lindberg and his wife Wendy also work to increase awareness of neuroblastoma among policymakers in Washington, DC and have successfully advanced new opportunities for federal support of neuroblastoma research within the Department of Defense.

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TWIPO #32 ~ Ethics in Childhood Cancer Clinical Trials

February 10th, 2014

October 18, 2013

Eric Kodish, MD, is a featured guest on the recent episode of This Week in Pediatric Oncology. In this episode, Dr. Kodish speaks with host Dr. Tim Cripe (Nationwide Children’s Hospital), and co-host Dr. Andy Kolb (AI DuPont), about informed consent and ethics surrounding childhood cancer clinical trials.

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TWIPO #31 ~ Secondary Cancers in Childhood Cancer Survivors

February 10th, 2014

October 03, 2013

Dr. Joseph Neglia (University of Minnesota) is nationally and internationally recognized for his contributions to the field of childhood cancer long-term effects. He is the featured guest in this week's podcast episode, and answers questions from host Dr. Tim Cripe (Nationwide Children’s Hospital), and co-hosts Dr. Robyn Dennis (Nationwide Children’s Hospital), Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids’ Cancer), about late effects and the risk of secondary cancers among childhood cancer survivors.

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TWIPO #30 ~ Cancer Risk in Families

February 10th, 2014

September 19, 2013

Recently, several published papers have discussed the risk of cancer among family members of children with cancer. TWIPO host Dr. Timothy Cripe and fellow co-host Dr. Robyn Dennis (Nationwide Children's) break down the topic of familial cancer risk with certified genetic counselor Elizabeth Varga (Nationwide Children's) and Donna Ludwinski (Solving Kids' Cancer) and what families should take away from these studies.

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TWIPO #29 ~ Understanding the Circuitry Behind Pediatric Solid Tumors

February 10th, 2014

September 05, 2013

New revelations in DNA damage and cell repair mechanisms in childhood cancer may help scientists identify the underlying cause of pediatric solid tumors and lead to the development of new therapies. Dr. Peter Houghton (Nationwide Children's) speaks with TWIPO host Dr. Timothy Cripe and fellow co-hosts Dr. Lionel Chow (Cincinatti Children's) and Dr. Robyn Dennis (Nationwide Children's) about his recent paper published in the Proceedings of the National Academy of Sciences on the mTOR pathway and role of ATM.

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TWIPO #28 ~ Uniting the Childhood Cancer Community

February 10th, 2014

August 15, 2013

TWIPO host Dr. Tim Cripe (Nationwide Children's) and co-hosts speak with Vickie Buenger from Texas A&M University about her role as a childhood cancer advocate. A founding member of the Coalition Against Childhood Cancer, Buenger discusses the organization's principles and future projects to bring the childhood cancer community together.

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TWIPO #27 ~ Advocating for Better Research for our Kids

February 10th, 2014

August 01, 2013

In this new episode, host Dr. Tim Cripe (Nationwide Children's) and co-host Dr. Jeffrey Auletta (Nationwide Children's) interview Solving Kids' Cancer co-founder and Executive Director Scott Kennedy and co-director of research programs Donna Ludwinski. Both Scott and Donna share their personal stories that led them to Solving Kids' Cancer and their shared passion to improve survival for children with the deadliest childhood cancers through research advocacy.

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TWiPO #26 ~ Killer Immunoglobulin Receptor (KIR) Mismatch in Neuroblastoma

February 10th, 2014

May 07, 2012

In this interesting episode, host Dr. Tim Cripe (Nationwide Children's) and co-hosts Dr. Lionel Chow (Cincinnati Children's), Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids' Cancer) quiz Dr Paul Sondel and Dr. Ken DeSantes (both from University of Wisconsin - Madison) on NK cells and the implications of KIR/KIR-ligand mismatch (killer immunoglobulin-like receptor) with regard to immunotherapy treatment of neuroblastoma.

References:

Delgado DC, Hank JA, Kolesar J, Lorentzen D, et al. Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res. 2010 Dec 1;70(23):9554-61. Epub 2010 Oct 8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999644/

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Venstrom JM, Zheng J, Noor N, Danis KE, et al. KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma. Clin Cancer Res. 2009 Dec 1;15(23):7330-4. Epub 2009 Nov 24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788079/

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Alderson KL, Sondel PM. Clinical cancer therapy by NK cells via antibody-dependent cell-mediated cytotoxicity. J Biomed Biotechnol. 2011;2011:379123. Epub 2011 May 24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110303/

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TWiPO #25 ~ Histones in Pediatric Gliomas

February 10th, 2014

April 05, 2012

Host Dr. Tim Cripe welcomes back co-host Dr. Lionel Chow to discuss somatic mutations in pediatric brain tumors. After recapping the consensus paper on molecular subgroups in medulloblastoma discussed in TWiPO episode 22 (Brain Tumor Round Robin) Dr Chow highlights the significance of the driver mutations in histone H3.3 in pediatric glioblastoma. Results of whole exome sequencing have shown that significantly more somatic mutations are present in adult tumors compared to pediatric tumors. This difference might suggest a reason for better success rates in pediatric tumors and possibly more escape mechanisms in adult tumors. Dr. Chow also discusses a paper published by the Pediatric Cancer Genome Project (a St. Jude Children's Research Hospital–Washington University collaboration) on somatic histone H3 alterations in diffuse intrinsic pontine glioma (DIPG). The findings are significant in showing that this mutation is present in 36% of non-brain stem gliomas and in 78% of brain stem gliomas, but in none of the other pediatric tumor types.

Please send comments and questions to twipo@solvingkidscancer.org

Papers discussed:

Taylor MD, Northcott PA, Korshunov A, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012 Apr;123(4):465-72. Epub 2011 Dec 2.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/

Schwartzentruber J, Korshunov A, Liu XY, Jones DT, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012 Jan 29;482(7384):226-31. doi: 10.1038/nature10833. http://www.ncbi.nlm.nih.gov/pubmed/22286061

Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29;44(3):251-3. doi: 10.1038/ng.1102. St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.http://www.ncbi.nlm.nih.gov/pubmed/22286216

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