TWiPO #88: The ACCELERATE ALKi Pediatric Strategy Forum with Prof. Andy Pearson & Prof. Lou Chesler

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/zZiE19fhzQQ
Tune in to the latest TWiPO episode as hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Prof. Andy Pearson and Prof. Lou Chesler to discuss the ACCELERATE forums; Prof. Pearson & Prof. Chesler played pivotal roles in the start of the ALKi Pediatric Strategy Forum. Listen in as they discuss their experiences from the very first meeting, how topics are chosen, and the importance of bringing together key people from different industries. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer.
To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/

TWiPO #87: Biotech Solutions for Pediatric Cancer Drug Development with Dr. Samuel Blackman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/PbNS-yFDTzA
Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Samuel Blackman to discuss biotech solutions for pediatric cancer drug development. Dr. Blackman is the Co-Founder and Chief Medical Officer of Day One Biopharmaceuticals located in South San Francisco, CA. Tune in as Dr. Blackman discusses his career journey, the origins of Day One, and the challenges in pediatric cancer drug development today.
To learn more about Day One Biopharmaceuticals, go to https://dayonebio.com/.
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Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

TWiPO #84: An Introduction to the ACCELERATE Platform with Dr. Gilles Vassal & Patricia Blanc

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/R_GyqL36_dg
Hosts Dr. Tim Cripe and Dr. Brenda Weigel met with Dr. Gilles Vassal and Patricia Blanc on the ACCELERATE Platform: Innovation for Children and Adolescents with Cancer. Dr. Gilles Vassal is the head of Clinical Research at Institut Gustave Roussy in Villejuif, France & he is also the Chair for the ACCELERATE Steering Committee. Patricia Blanc is the President & Founder of the Imagine for Margo Foundation and serves as a Patient Advocate for ACCELERATE. Listen in to hear how the ACCELERATE platform came to be & the advances they are making within the childhood cancer research landscape. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer.
To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/
 

Discussing Brain Tumor Research with Dr. Michael Taylor & Dr. Nabil Ahmed

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/TwBmCwq3gJc
This week was International Brain Tumor Awareness Week & we're closing out the week with this engaging discussion. TWIPO Host, Dr. Timothy Cripe, met with Dr. Michael Taylor, from SickKids in Toronto, Canada, and Dr. Nabil Ahmed, from Texas Children's Hospital, to discuss their recently published paper on a novel immunotherapy approach for children with metastatic medulloblastoma and ependymoma.
You can read their full paper here: https://pubmed.ncbi.nlm.nih.gov/32341580/

TWiPO #75 - Interview with Dr. Robert Wechsler-Reya

Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with co-host - Dr. Nilay Shah, are joined by Dr. Robert Wechsler-Reya from Sanford Burnham Prebys in San Diego, CA. They discuss Dr. Wechsler-Reya's work including the process, benefits, and limitations of tumor models in mice, as well as research behind the humanized mouse model. They also discuss immune evasion - how one tumor type can grow in the presence of an immune system, while another one cannot. Listen in to learn more.
Please send questions and comments to TWiPO@solvingkidscancer.org.

TWiPO #72 - Dr. Eugene Hwang discusses his work with immunotherapy and pseudo-progression

Hosts, Dr. Timothy Cripe, Dr. Keri Steby, Dr. Ryan Roberts, and Dr. Jonathan Finlay from Nationwide Children's Hospital are joined by Dr. Eugene Hwang, who is a pediatric hematologist-oncologist at the Children's National Medical Center in Washington D.C. Dr. Hwang discusses his work with immunotherapy and pseudo-progression, as well as explains the basics of a solid tumor clinical trial he created in conjunction with Dr. Catherine Bollard. Listen in to learn more.

TWIPO #66 - Interview with Dr. Rani George

Host Dr. Ryan Roberts, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Rani George to discuss her experience with studying neuroblastoma and how she got involved in the field of oncology. George discusses her thoughts on what is needed to progress pediatric cancer research - including relapse biopsies, understanding the biology, and, of course, funding. As Dr. Roberts says, what we need is, "...more time, more patience, and more funding."  Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #65 - Interview with Dr. Brenda Weigel

In this podcast, co-Hosts Dr. Robyn Dennis and Dr. Ryan Roberts had the honor of interviewing Dr. Brenda Weigel, Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota. Dr. Weigel discusses her “serendipitous” background story of how she became involved in childhood oncology, as well as talks about the challenges the field faces with managing new cancer therapies. But, despite the challenges, she is hopeful that we are moving away from chemotherapy treatments into an era of cancer therapies that “hopefully, has the potential to cure the cancers and improve the quality of life”. 

TWiPO #64 - Interview with Dr. Lars Wagner

It’s an exciting time to be part of the childhood cancer research community, and this interview was focused on career advice for those interested in childhood oncology and research. The availability of genomic profiling of tumors, targeted agents and the development of new immunotherapies are increasing the opportunities available to patients today. This lively discussion addresses the importance of preclinical data, predictive biomarker studies and the measurement of responses, with specific references to Dr. Wagner’s experience with studying irinotecan.   Dr. Wagner also answered questions about radiomics and how this imaging trend can provide more insights for enhanced radiology reporting.
Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #58 ~ Interview with Dr. Damon Reed

TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development.