TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/rFd4Fwa_XVg
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids’ Cancer’s patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.
 
You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111
 
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TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q
In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments.
You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco
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TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/AFmMxBeZOa4
Tune in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Rimas Orentas - the Scientific Director of Caring Cross & a Professor from Seattle Children's Hospital. In this episode, Dr. Orentas discusses his expertise in cellular gene therapy - the accessibility, production, testing, and the importance of diversity and inclusion amongst research subjects.
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TWiPO #92: mRNA - Not just for COVID - What is its Application in Pediatric Cancer? with Dr. Elias Sayour

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/uk1dxJe3VoY
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Elias Sayour from the University of Florida. While many are familiar with mRNA due to its COVID-19 vaccine application, Dr. Sayour discusses mRNA within the pediatric brain tumor landscape - including preclinical work, its delivery & distribution, as well as promising future opportunities for pediatric cancer patients.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #91: What Breakthroughs are on the Horizon for DIPG? with Dr. Mariella Filbin

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/7NAibEpTA0w
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Mariella Filbin from Dana-Farber Cancer Institute/Boston Children's Hospital. Dr. Filbin discusses her expertise within DIPG including transcriptomics and epigenomics, as well as what is on the horizon for research - both challenging and exciting advances.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #90: Newborn Screening For Predisposition to Pediatric Cancers with Dr. Lisa Diller

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Fd1flMgbfLw
Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Lisa Diller from Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dr. Diller discusses the possibilities of genetic testing for pediatric cancer predisposition syndromes in newborn screening programs, but with uncertain benefits and costs. She recently authored a paper exploring mathematical modeling of a screening program for cost and benefit.
You can read her full paper here: https://pubmed.ncbi.nlm.nih.gov/33767345/

TWiPO #89: Spotlight on Immunotherapy for Pediatrics - Natural Killer T-Cells with Dr. Andras Heczey

WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=nJZYz1XrsyY
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Andras Heczey from Texas Children's Hospital/Baylor College of Medicine. Listen in as they discuss Dr. Heczey's expertise & research in utilizing Natural Killer (NK) T-cells for pediatric immunotherapy treatment and the process of doing so.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #87: Biotech Solutions for Pediatric Cancer Drug Development with Dr. Samuel Blackman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/PbNS-yFDTzA
Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Samuel Blackman to discuss biotech solutions for pediatric cancer drug development. Dr. Blackman is the Co-Founder and Chief Medical Officer of Day One Biopharmaceuticals located in South San Francisco, CA. Tune in as Dr. Blackman discusses his career journey, the origins of Day One, and the challenges in pediatric cancer drug development today.
To learn more about Day One Biopharmaceuticals, go to https://dayonebio.com/.
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TWiPO #86: Oncolytic Virotherapy in Pediatric Brain Tumors with Dr. Gregory Friedman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/OSftR6JhEtY
As Brain Tumor Awareness Month draws to a close, we bring you a new TWIPO episode on the subject. Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Gregory Friedman from the University of Alabama in Birmingham to discuss his recently published paper “Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.” Listen in as Dr. Friedman discusses the findings of this phase 1 clinical trial and the progress of oncolytic virotherapy in pediatric brain tumors.
You can access the abstract to Dr. Friedman's paper here: https://pubmed.ncbi.nlm.nih.gov/33838625/
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.
Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

TWiPO #85: Brain Tumors & The Blood-Brain Barrier with Dr. Stergios Zacharoulis

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/TEFcsd5lt1A
In recognition of Brain Tumor Awareness Month, TWIPO hosts Dr. Timothy Cripe and Dr. Brenda Weigel are joined by Dr. Stergios Zacharoulis of Columbia University Irving Medical Center (CUIMC), where he initiated a novel drug delivery program for pediatric brain tumors. Listen in as Dr. Zacharoulis discusses different delivery methodologies being explored and developed that bypass the blood brain barrier.
 
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