TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ
Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors. 
 
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #89: Spotlight on Immunotherapy for Pediatrics - Natural Killer T-Cells with Dr. Andras Heczey

WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=nJZYz1XrsyY
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Andras Heczey from Texas Children's Hospital/Baylor College of Medicine. Listen in as they discuss Dr. Heczey's expertise & research in utilizing Natural Killer (NK) T-cells for pediatric immunotherapy treatment and the process of doing so.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

TWiPO #86: Oncolytic Virotherapy in Pediatric Brain Tumors with Dr. Gregory Friedman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/OSftR6JhEtY
As Brain Tumor Awareness Month draws to a close, we bring you a new TWIPO episode on the subject. Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Gregory Friedman from the University of Alabama in Birmingham to discuss his recently published paper “Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.” Listen in as Dr. Friedman discusses the findings of this phase 1 clinical trial and the progress of oncolytic virotherapy in pediatric brain tumors.
You can access the abstract to Dr. Friedman's paper here: https://pubmed.ncbi.nlm.nih.gov/33838625/
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.
Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

Discussing Brain Tumor Research with Dr. Michael Taylor & Dr. Nabil Ahmed

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/TwBmCwq3gJc
This week was International Brain Tumor Awareness Week & we're closing out the week with this engaging discussion. TWIPO Host, Dr. Timothy Cripe, met with Dr. Michael Taylor, from SickKids in Toronto, Canada, and Dr. Nabil Ahmed, from Texas Children's Hospital, to discuss their recently published paper on a novel immunotherapy approach for children with metastatic medulloblastoma and ependymoma.
You can read their full paper here: https://pubmed.ncbi.nlm.nih.gov/32341580/

TWiPO #75 - Interview with Dr. Robert Wechsler-Reya

Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with co-host - Dr. Nilay Shah, are joined by Dr. Robert Wechsler-Reya from Sanford Burnham Prebys in San Diego, CA. They discuss Dr. Wechsler-Reya's work including the process, benefits, and limitations of tumor models in mice, as well as research behind the humanized mouse model. They also discuss immune evasion - how one tumor type can grow in the presence of an immune system, while another one cannot. Listen in to learn more.
Please send questions and comments to TWiPO@solvingkidscancer.org.

TWiPO #71 - Interview with Nancy Goodman, Founder and Executive Director of Kids v. Cancer

Host, Dr. Timothy Cripe, from Nationwide Children's Hospital in Columbus, Ohio had the honor of interviewing Nancy Goodman, Founder and Executive Director of Kids v. Cancer in Washington DC.

TWiPO #58 ~ Interview with Dr. Damon Reed

TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development. 

TWIPO #56 ~ Interview with Dr. Mark Hatley

On today's podcast, TWIPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host Dr. Ryan Roberts (Nationwide Children’s Hospital) interview Dr. Mark Hatley (St. Jude Children's Research Hospital). Dr. Hatley discusses how he got into the field of Biological Chemistry in Oncology. Also Dr. Hatley gives an indepth explaination about his research in G-Proteins.

TWIPO #50 ~ Interview With Dr. Jonathan Finlay

In this most recent TWiPO podcast hosted by Dr. Timothy Cripe (Nationwide Children’s Hospital), he interviews Dr. Jonathan Finlay (Program Director of Neuro-Oncology at Nationwide Children’s Hospital) about sparked in research interest in brain tumors. One of Dr. Finlay’s mentors, helped launch a new treatment, which was able to rescue a proportion of newly diagnosed children who failed conventional chemotherapy, radiation, and surgery. That novel treatment is now a growing method of treating medulloblastoma.

TWiPO #8 ~ Seneca Valley virus and medulloblastoma

June
09, 2011
An oncolytic virus
for a common childhood brain tumor
In this eighth episode of "This Week in Pediatric
Oncology" podcast hosts Dr. Tim Cripe, Dr. Lars Wagner and Dr. Lionel Chow
discuss a recent publication by researchers at Baylor/Texas Children's in
Houston that shows remarkable results of Seneca Valley virus SVV-001 on
orthotopic mouse models of medulloblastoma.
The TWiPO hosts raise many interesting points
about this research and highlight the strengths as well as limitations of this
work. This exciting research provides new evidence of promise for oncolytic
virus therapy for childhood tumors.
For more information about oncolytic virus
trials for pediatric cancers, see a recent webinar "Oncolytic Virotherapy for
Pediatric Solid Tumors" presented by the principal
investigators of five clinical trials in children and sponsored by Solving
Kids' Cancer.
The article discussed in this episode can be
found here:
A single intravenous injection of oncolytic picornavirus SVV-001
eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse
models. Yu L, Baxter PA, et al. Neuro Oncol. 2011
Jan;13(1):14-27. Epub 2010 Nov 12.
Another related article by the same group:
Treatment of invasive retinoblastoma in a murine model using an oncolytic
picornavirus. Wadhwa L, Hurwitz MY, et al. Cancer Res. 2007
Nov 15;67(22):10653-6. [fulltext]
Please send questions or comments to
twipo@solvingkidscancer.org