TWiPO #92: mRNA - Not just for COVID - What is its Application in Pediatric Cancer? with Dr. Elias Sayour

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/uk1dxJe3VoY
Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Elias Sayour from the University of Florida. While many are familiar with mRNA due to its COVID-19 vaccine application, Dr. Sayour discusses mRNA within the pediatric brain tumor landscape - including preclinical work, its delivery & distribution, as well as promising future opportunities for pediatric cancer patients.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #88: The ACCELERATE ALKi Pediatric Strategy Forum with Prof. Andy Pearson & Prof. Lou Chesler

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/zZiE19fhzQQ
Tune in to the latest TWiPO episode as hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Prof. Andy Pearson and Prof. Lou Chesler to discuss the ACCELERATE forums; Prof. Pearson & Prof. Chesler played pivotal roles in the start of the ALKi Pediatric Strategy Forum. Listen in as they discuss their experiences from the very first meeting, how topics are chosen, and the importance of bringing together key people from different industries. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer.
To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/

TWiPO #87: Biotech Solutions for Pediatric Cancer Drug Development with Dr. Samuel Blackman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/PbNS-yFDTzA
Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Samuel Blackman to discuss biotech solutions for pediatric cancer drug development. Dr. Blackman is the Co-Founder and Chief Medical Officer of Day One Biopharmaceuticals located in South San Francisco, CA. Tune in as Dr. Blackman discusses his career journey, the origins of Day One, and the challenges in pediatric cancer drug development today.
To learn more about Day One Biopharmaceuticals, go to https://dayonebio.com/.
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.
Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

TWiPO #84: An Introduction to the ACCELERATE Platform with Dr. Gilles Vassal & Patricia Blanc

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/R_GyqL36_dg
Hosts Dr. Tim Cripe and Dr. Brenda Weigel met with Dr. Gilles Vassal and Patricia Blanc on the ACCELERATE Platform: Innovation for Children and Adolescents with Cancer. Dr. Gilles Vassal is the head of Clinical Research at Institut Gustave Roussy in Villejuif, France & he is also the Chair for the ACCELERATE Steering Committee. Patricia Blanc is the President & Founder of the Imagine for Margo Foundation and serves as a Patient Advocate for ACCELERATE. Listen in to hear how the ACCELERATE platform came to be & the advances they are making within the childhood cancer research landscape. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer.
To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/
 

TWIPO #66 - Interview with Dr. Rani George

Host Dr. Ryan Roberts, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Rani George to discuss her experience with studying neuroblastoma and how she got involved in the field of oncology. George discusses her thoughts on what is needed to progress pediatric cancer research - including relapse biopsies, understanding the biology, and, of course, funding. As Dr. Roberts says, what we need is, "...more time, more patience, and more funding."  Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #65 - Interview with Dr. Brenda Weigel

In this podcast, co-Hosts Dr. Robyn Dennis and Dr. Ryan Roberts had the honor of interviewing Dr. Brenda Weigel, Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota. Dr. Weigel discusses her “serendipitous” background story of how she became involved in childhood oncology, as well as talks about the challenges the field faces with managing new cancer therapies. But, despite the challenges, she is hopeful that we are moving away from chemotherapy treatments into an era of cancer therapies that “hopefully, has the potential to cure the cancers and improve the quality of life”. 

TWiPO #64 - Interview with Dr. Lars Wagner

It’s an exciting time to be part of the childhood cancer research community, and this interview was focused on career advice for those interested in childhood oncology and research. The availability of genomic profiling of tumors, targeted agents and the development of new immunotherapies are increasing the opportunities available to patients today. This lively discussion addresses the importance of preclinical data, predictive biomarker studies and the measurement of responses, with specific references to Dr. Wagner’s experience with studying irinotecan.   Dr. Wagner also answered questions about radiomics and how this imaging trend can provide more insights for enhanced radiology reporting.
Please send questions and comments to TWiPO@solvingkidscancer.org 

TWiPO #63 - Dr. Javier Blanco discusses chemotherapy late effects and cardio-toxicity

Co-Hosts Dr. Timothy Cripe and Dr. Randal Olshefski (Nationwide Children's Hospital), interview Dr. Javier Blanco, Associate Professor at the Department of Pharmaceutical Sciences at SUNY Buffalo, about the late effects of chemotherapy.  In this podcast, the participants discuss the role that chemotherapy, such as doxorubicin and other anthracycline drugs, often play in increasing cardio-toxicity.

TWiPo #59 ~ Interview with Dr. Sajid Qureshi

Host Dr. Timothy Cripe and co-Host Nilay Shah interview Dr. Sajid Qureshi, a professor of Pediatric Oncology at the Tata Memorial Center, Mumbai, India. Dr. Qureshi is an Executive Committee Member of the International Society of Pediatric Surgical Oncology (IPSO). In this episode Dr. Qureshi provides a fascinating, first-hand glimpse into the successes and challenges of delivering quality care to larger, as well as remote, pediatric cancer populations. The episode concludes with Dr. Qureshi's thoughts on how international research collaboration could provide access to relapsed children worldwide.

TWiPO #58 ~ Interview with Dr. Damon Reed

TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development.