TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh

Listen in & join the TWiPO team in this special live recorded episode. Our host, Dr. Tim Cripe, along with his Nationwide Children’s Hospital colleagues, Dr. Ryan Roberts, Dr. Elaine Mardis & Dr. Katherine Miller, are joined by Dr. Trevor Pugh, who is a clinical laboratory geneticist from the University of Toronto in Canada. Tune in as they all discuss Dr. Pugh’s specialty in genomics & his recent work regarding the early identification of cancers in patients with Li Fraumeni Syndrome. 
To learn more about this study, visit https://www.medrxiv.org/content/10.1101/2022.10.07.22280848v1.full.pdf

TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Z1D-7i4oy1s
 
Our host, Dr. Timothy Cripe from Nationwide Children's Hospital, is joined by Dr. Martin McCabe from the University of Manchester to discuss the results of the rEECur trial. The rEECur trial is an international randomized trial conducted on recurrent and primary refractory Ewing sarcoma patients. Dr. McCabe leads a discussion on the genesis of rEECur, what it entailed & what was learned from conducting this trial.
 
To learn more about this trial, please visit https://www.manchester.ac.uk/discover/news/study-identifies-best-treatment-for-rare-childhood-cancer/

TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/41kwZNhrBBc
This Week in Pediatric Oncology #104 - December 13, 2022
In this episode, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Joshua Schiffman - CEO & Co-Founder of PEEL Therapeutics, Inc. Dr. Schiffman’s own personal childhood cancer journey paved his way into the pediatric cancer field. Listen in as he discusses the formation of PEEL, their research work utilizing nanoparticles & nanotechnology, and the opportunities/challenges that are in PEEL’s future.
To learn more about PEEL Therapeutics, Inc, please visit https://peeltx.com/

TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/SkyYLIZxQWA
This Week in Pediatric Oncology #103 - November 30, 2022
Join us as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Roger Packer from Children’s National Hospital in Washington DC. Dr. Packer is the Senior Vice President of the Center for Neurosciences and Behavioral Medicine at Children’s National, which is introducing a low-intensity focused ultrasound (LIFU) therapy. Listen in as Dr. Packer discusses what LIFU is and the exciting new techniques and technologies behind it.
To learn more, you can visit https://childrensnational.org/news-and-events/childrens-newsroom/2022/a-pediatric-brain-tumor-first-opening-the-blood-brain-barrier-to-deliver-targeted-therapies

TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/inNQc6x9Jy8
This Week in Pediatric Oncology #102 - November 10, 2022
Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined again by Dr. Douglas Hawkins - who is the current Chair of the Children’s Oncology Group (COG). They discuss in depth the findings of a presented published paper regarding the inequities of childhood cancer outcomes based on external socioeconomic factors such as neighborhood and household poverty.
To read the full paper, visit https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7936051&blobtype=pdf

This Week in Pediatric Oncology - 100th Episode

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/8Lj3uFHWo60
Happy 100th Episode to the This Week in Pediatric Oncology Podcast! In this special milestone episode, our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Scott Kennedy & Donna Ludwinski from Solving Kids' Cancer to reminisce on the history & creation of TWiPO and talk about their favorite podcast episodes from over the years.

TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/bDbtses4w2E
Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Samuel Volchenboum who is an Associate Professor of Pediatrics from the University of Chicago. Dr. Volchenboum spearheaded an international effort through two data platforms called the Pediatric Cancer Data Commons (PCDC) & GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes). Listen in as he explains the importance behind these two platforms, as well as the challenges and barriers to data collaboration.
 
To learn more about the Pediatric Cancer Data Commons, you can visit http://commons.cri.uchicago.edu
To learn more about GEARBOx, you can visit http://gearbox.pedscommons.org

TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/5TYFsjh91Tw
Listen in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Robbie Majzner - an Assistant Professor of Pediatrics in the Division of Hematology and Oncology at Stanford University's School of Medicine. Dr. Majzner goes into great detail about his recent clinical trial on GD2-CAR T cell therapy for H3K27M-mutated Diffuse Midline Gliomas - the findings, the process, and what the future holds. You can read more about Dr. Majzner's study here: https://www.nature.com/articles/s41586-022-04489-4
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ
Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors. 
 
Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman

WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q
In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments.
You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco
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Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast