This Week in Pediatric Oncology

This Week in Pediatric Oncology header image 1

Entries Tagged as 'brain tumor'

TWiPo #59 ~ Interview with Dr. Sajid Qureshi

October 17th, 2016 · Comments

Host Dr. Timothy Cripe and co-Host Nilay Shah interview Dr. Sajid Qureshi, a professor of Pediatric Oncology at the Tata Memorial Center, Mumbai, India. Dr. Qureshi is an Executive Committee Member of the International Society of Pediatric Surgical Oncology (IPSO). In this episode Dr. Qureshi provides a fascinating, first-hand glimpse into the successes and challenges of delivering quality care to larger, as well as remote, pediatric cancer populations. The episode concludes with Dr. Qureshi's thoughts on how international research collaboration could provide access to relapsed children worldwide.

00:0000:00

Tags: families · cancer · children · pediatric cancer · childhood cancer · drug development · neuroblastoma · research · brain tumor · clinical trials · Advancement in Cancer Research

TWiPO #58 ~ Interview with Dr. Damon Reed

October 17th, 2016 · Comments

TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development. 

00:0000:00

Tags: families · cancer risk · cancer · children · pediatric cancer · childhood cancer · drug development · neuroblastoma · medulloblastoma · sarcoma · research · brain tumor · immunotherapy · clinical trials · Advancement in Cancer Research

TWIPO #56 ~ Interview with Dr. Mark Hatley

September 6th, 2016 · Comments

On today's podcast, TWIPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host Dr. Ryan Roberts (Nationwide Children’s Hospital) interview Dr. Mark Hatley (St. Jude Children's Research Hospital). Dr. Hatley discusses how he got into the field of Biological Chemistry in Oncology. Also Dr. Hatley gives an indepth explaination about his research in G-Proteins.

00:0000:00

Tags: cancer · children · pediatric cancer · childhood cancer · drug development · neuroblastoma · medulloblastoma · research · brain tumor · immunotherapy · clinical trials · Advancement in Cancer Research

TWiPO #55 ~ Interview with Dr. Chrystal Louis

June 3rd, 2016 · Comments

On this episode of TWiPO podcast Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host, Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri A. Streby (Nationwide Children's Hospital) interview Dr. Chrystal Louis (Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine.) Dr. Louis talks to the hosts about her role in both the academic and industry side of oncology. 

00:0000:00

Tags: cancer · children · pediatric cancer · childhood cancer · drug development · research · brain tumor · clinical trials · Advancement in Cancer Research

TWiPO #54 ~ Interview with Dr. Kim Kramer

June 3rd, 2016 · Comments

On today's TWiPO Podcast host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host, Dr. Nilay Shah (Nationwide Children’s Hospital) interview Dr. Kim Kramer (Pediatric Oncologist of Memorial Sloan Kettering.) In this interview they discuss a new cutting edge therapy for treating brain tumors, which involves targeting the tumor intravenously just like any other tumor.

00:0000:00

Tags: families · cancer · children · pediatric cancer · childhood cancer · drug development · brain tumor

TWiPO #53 ~ Interview with Linda McAllister-Lucas

April 13th, 2016 · Comments

On today's podcast TWiPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-hosts, Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Robyn Dennis (Nationwide Children’s Hospital) Interview Dr. Linda McAllister-Lucas (Chief of Service, Hematology/Oncology of Children's Hospital of Pittsburgh, Associate Professor of Pediatrics, University of Pittsburgh School of Medicine. In their discussion Dr. McAllister-Lucas talks about her research on MALT1 Lymphoma and how this research could advance the field of oncology 

00:0000:00

Tags: cancer risk · cancer · children · pediatric cancer · childhood cancer · drug development · research · brain tumor · Advancement in Cancer Research

TWIPO #50 ~ Interview With Dr. Jonathan Finlay

May 8th, 2015 · Comments

In this most recent TWiPO podcast hosted by Dr. Timothy Cripe (Nationwide Children’s Hospital), he interviews Dr. Jonathan Finlay (Program Director of Neuro-Oncology at Nationwide Children’s Hospital) about sparked in research interest in brain tumors. One of Dr. Finlay’s mentors, helped launch a new treatment, which was able to rescue a proportion of newly diagnosed children who failed conventional chemotherapy, radiation, and surgery. That novel treatment is now a growing method of treating medulloblastoma.

00:0000:00

Tags: pediatric cancer · childhood cancer · medulloblastoma · profile interview · brain tumor

TWIPO #45 ~ Immunotherapy Vaccine for Immunotherapy Vaccine for High-Grade Gliomas

November 18th, 2014 · Comments

In the most recent episode of This Week in Pediatric Oncology, co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital), Dr. Timothy Cripe (Nationwide Children’s Hospital), and Dr. Lionel Chow (Cincinnati Children’s) discuss the promising results of a study published in the July issue of Journal of Clinical Oncology among children with an aggressive brain tumor after receiving immunotherapy. To see a summary of the study, click here

00:0000:00

Tags: brain tumor · immunotherapy · vaccines

TWIPO #35 ~ Interview With Robert Johnson, PhD

February 10th, 2014 · Comments

December 02, 2013

New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Robert Johnson, PhD, is a featured guest on its most recent episode, In this episode, Dr. Johnson speaks with host Dr. Tim Cripe (Nationwide Children's Hospital) and co-hosts Dr. Robyn Dennis (Nationwide Children's Hospital and Dr. Lionel Chow (Cincinatti Children's) about the third most common type of brain tumor in children, ependymomas.

Robert A. Johnson, PhD, is a principal investigator at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of the Johnson laboratory is the development of novel therapies for the treatment of ependymoma, the third most common pediatric brain tumor, by identifying and targeting the genetic changes responsible for the formation of the disease.

00:0000:00

Tags: childhood cancer · ependymomas · research · brain tumor

TWiPO #25 ~ Histones in Pediatric Gliomas

February 10th, 2014 · Comments

April 05, 2012

Host Dr. Tim Cripe welcomes back co-host Dr. Lionel Chow to discuss somatic mutations in pediatric brain tumors. After recapping the consensus paper on molecular subgroups in medulloblastoma discussed in TWiPO episode 22 (Brain Tumor Round Robin) Dr Chow highlights the significance of the driver mutations in histone H3.3 in pediatric glioblastoma. Results of whole exome sequencing have shown that significantly more somatic mutations are present in adult tumors compared to pediatric tumors. This difference might suggest a reason for better success rates in pediatric tumors and possibly more escape mechanisms in adult tumors. Dr. Chow also discusses a paper published by the Pediatric Cancer Genome Project (a St. Jude Children's Research Hospital–Washington University collaboration) on somatic histone H3 alterations in diffuse intrinsic pontine glioma (DIPG). The findings are significant in showing that this mutation is present in 36% of non-brain stem gliomas and in 78% of brain stem gliomas, but in none of the other pediatric tumor types.

Please send comments and questions to twipo@solvingkidscancer.org

Papers discussed:

Taylor MD, Northcott PA, Korshunov A, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012 Apr;123(4):465-72. Epub 2011 Dec 2.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/

Schwartzentruber J, Korshunov A, Liu XY, Jones DT, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012 Jan 29;482(7384):226-31. doi: 10.1038/nature10833. http://www.ncbi.nlm.nih.gov/pubmed/22286061

Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29;44(3):251-3. doi: 10.1038/ng.1102. St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.http://www.ncbi.nlm.nih.gov/pubmed/22286216

00:0000:00

Tags: childhood cancer · research · brain tumor

TWiPO #22 ~ Brain Tumor Year-End Round Robin

February 10th, 2014 · Comments

December 05, 2011

Join Dr. Tim Cripe and his co-host Dr. Lionel Chow for a fast-paced, in-depth, and comprehensive survey of 15 important recent papers on pediatric brain tumor research, addressing medulloblastoma, ependymomas, and gliomas. Dr. Cripe and Dr. Chow explore and discuss the compelling evidence reported on a variety of topics, including viral causes and therapeutic implications, biomarkers, genomics, proteomics, targets, classification, risk stratification, treatment side-effects, proton-beam radiation therapy, and results of recent clinical trials.

This robust review of current research includes all of the following papers [click link], listed by timed location in the podcast.

Please send all comments and questions to twipo@solvingkidscancer.org

00:0000:00

Tags: childhood cancer · brain tumor